Home > Library > NESTEC 2021 PAPER: Organometallic Compounds: Its Therapeutic Potentials Towards Cancer Treatment

NESTEC 2021 PAPER: Organometallic Compounds: Its Therapeutic Potentials Towards Cancer Treatment

ABSTRACT

Organometallic compounds are renowned for their remarkable applications in the field of catalysis, but much less is known about their potential in chemical biology. Indeed, such compounds have long been considered to be either unstable under physiological conditions or cytotoxic. As a consequence, little attention has been paid to their possible utilization for biological purposes. Because of their outstanding physicochemical properties, which include chemical stability, structural diversity and unique photo-and electrochemical properties, however, organometallic compounds can play a leading role in the field of chemical biology. Indeed, remarkable examples of the use of such compounds-notably as enzyme inhibitors and as luminescent agents-have recently been reported. Here, recent advances in the use of organometallic compounds for chemical biology purposes, an area that we define as ‘organometallic chemical biology’. We also demonstrate that these recent discoveries are only a beginning and that many other organometallic complexes are likely to be found useful in this field of research soon. Inorganic and organometallic compounds have been used as pesticides. At present, in most developed countries, only copper compounds are used in a significant amount as fungicides. The others have been banned for either toxicological or environmental reasons. It is believed that organotins are still used in some developing countries. Copper compounds if used as directed do not pose health risks, however; the estimated long-term intake in the European Union is not much below the acceptable daily intake when other non-pesticidal sources of copper are considered. Organotins have no negligible acute toxicity. Triphenyltin has immunotoxic and, possible, carcinogenic effects and cyhexatin/azocyclotin have embryotoxic properties. However, estimated intakes are below reference values.

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Author: Taiwo Esther Omolola

Keywords: Organometallic Compounds, Clinical and Industrial Applications, Cancer Therapy.

 

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ORGANOMETALLIC COMPOUNDS -ITS THERAPEUTIC POTENTIALS TOWARDS CANCER TREATMENT

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19 thoughts on “NESTEC 2021 PAPER: Organometallic Compounds: Its Therapeutic Potentials Towards Cancer Treatment

  1. This is really insightful and thoughtful
    Organometallic compounds though many are hazardous but they are naturally occurring organometallic compounds that can be harnessed into the therapy of cancer
    I applaud this write-up

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  2. Well I also agree that these compound are under used and also agree with this write up…… We really need to explore more and get to use this compounds more and I believe with this we could have breakthrough in our medical line

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  3. As much as Organometallic Compounds are useful, their hazardous effects cannot be ignored.

    Such an educative piece. Thank you so much.

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  4. The depth of this analysis of organometallic compound is truly outstanding, an excellently enlightening piece.

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  5. Amazing!

    “Organometallic Compounds has good Therapeutic potentials towards cancer treatment”.

    The Question is:Has the Pharmacokinetic profile of these drugs been ascertained in the human system?

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    1. Yes, metal-based compounds is widely used in treatment of disease conditions. The metal-based anticancer drugs such as the Platinum complexes are the main stay in the treatment of cancer, approximately half of all patients receiving cancer chemotherapy are treated with it.

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  6. Yes, metal-based compounds is widely used in treatment of disease conditions. The metal-based anticancer drugs such as the Platinum complexes are the main stay in the treatment of cancer, approximately half of all patients receiving cancer chemotherapy are treated with it.

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  7. Thank you, Taiwo.
    Following through from your previous reply, is there existing work on medicinal plants in Nigeria which suggest that these solutions can be obtained economically and sustainably?

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